Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

Name: Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole
Prep time: 20 min
Cook time: 35 min
Total time: 55 min
Cuisine: Southern
Ingredients: 3 cups cooked boneless, skinless chicken breasts (diced); 8 ounces spaghetti (cooked al dente); 1 can (10 ounces) spicy Ro-Tel tomatoes; 8 ounces cream cheese (softened); 2 cups shredded sharp cheddar cheese; 1 cup low-sodium chicken broth; 1 tsp garlic powder; 1 tsp onion powder; Salt and pepper to taste

By Elisa Levine

September 12, 2025

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Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole is a dish that tantalizes your taste buds with its creamy, cheesy goodness and spicy kick. Imagine a warm, bubbling casserole fresh from the oven, its savory aroma wafting through your kitchen like an inviting hug on a chilly day.

Every bite of this comforting dish combines tender chicken, perfectly cooked spaghetti, and a blend of spices that will dance on your palate. Whether it’s a cozy family dinner or a potluck with friends, this casserole promises to be the star of the show, leaving everyone begging for seconds.

Why You'll Love This Recipe

This Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole is quick to prepare and perfect for any occasion
With its rich flavors and creamy texture, it’s sure to please even the pickiest eaters
The vibrant colors make it pop on your dinner table, while its versatility allows for endless ingredient swaps!

Ingredients for Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

Here’s what you’ll need to make this delicious dish:

Boneless, Skinless Chicken Breasts: About 3-4 chicken breasts work best; adjust based on your crowd size.
Spaghetti: Use regular or whole wheat spaghetti; cook until al dente for the best texture.
Spicy Ro-Tel Tomatoes: These add a zesty kick; opt for mild if you prefer less heat.
Cream Cheese: For that luscious creaminess; let it soften at room temperature before using.
Shredded Cheddar Cheese: Use sharp cheddar for maximum flavor; feel free to mix in some Monterey Jack too!

For the Sauce:

Chicken Broth: Low-sodium broth ensures you control the saltiness without sacrificing flavor.
Garlic Powder: A must-have for depth and flavor—don’t skimp!
Onion Powder: This adds sweetness and aroma; it’s like magic in the air!

The full ingredients list, including measurements, is provided in the recipe card directly below.

Recipe preparation for Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

How to Make Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

Follow these simple steps to prepare this delicious dish:

Step 1: Preheat Your Oven

Preheat oven to 350°F (175°C). Grab a large baking dish and spray it with nonstick cooking spray.

Step 2: Cook the Pasta

Boil water in a large pot. Add spaghetti and cook until al dente according to package instructions. Drain and set aside.

Step 3: Prepare the Chicken

In a skillet over medium heat, sauté diced chicken breasts until golden brown and cooked through—about 7-10 minutes. Season with salt, pepper, garlic powder, and onion powder.

Step 4: Mix Everything Together

In a large bowl, combine cooked spaghetti, sautéed chicken, spicy Ro-Tel tomatoes, cream cheese, shredded cheddar cheese, and chicken broth. Stir until everything is well mixed and coated in cheesy goodness.

Step 5: Transfer to Baking Dish

Pour the mixture into your prepared baking dish. Sprinkle some extra cheese on top because we all know more cheese equals more happiness!

Step 6: Bake It Up

Bake in the preheated oven for about 30-35 minutes or until bubbly and golden brown on top.

Serve hot with a sprinkle of fresh parsley or green onions for that fancy touch! Trust me; this Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole will have everyone asking you what’s your secret—just don’t tell them how easy it was!

You Must Know

This Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole is more than just a comfort dish; it’s a guaranteed crowd-pleaser
With its rich flavors and creamy texture, it turns any meal into a celebration
Perfect for potlucks or cozy family dinners, everyone will be asking for seconds!

Perfecting the Cooking Process

Sear the chicken first to lock in those juicy flavors, then cook the pasta while preparing the creamy, cheesy sauce. Layer everything together in a casserole dish and bake until bubbly. This sequence ensures every bite is packed with flavor and perfectly cooked.

Add Your Touch

Feel free to swap out ingredients based on your pantry or cravings! Add some bell peppers for crunch or switch the cheese to pepper jack for an extra kick. You can even toss in some spinach if you’re feeling fancy!

Storing & Reheating

Store any leftovers in an airtight container in the fridge for up to three days. To reheat, pop it in the oven at 350 degrees until warmed through, or use the microwave if you’re in a hurry.

Chef's Helpful Tips

For perfect results, always ensure your chicken is cooked thoroughly before mixing with other ingredients
Don’t skip the resting time after baking; it helps set up those cheesy layers
Lastly, experiment with spices to find your ideal flavor balance!

It was one of those chilly nights when my friends decided to have an impromptu movie marathon. I whipped up this Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole, and let me tell you—the smiles on their faces were priceless!

FAQs :

What ingredients do I need for Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole?

To make this irresistible spicy southern cheesy chicken spaghetti casserole, you will need cooked chicken, spaghetti noodles, cream cheese, cheddar cheese, diced tomatoes, green chilies, and a blend of spices. You can also include bell peppers and onions for added flavor. This combination creates a creamy, cheesy dish that is full of zest and southern charm. Make sure to gather all your ingredients before starting the cooking process to ensure everything goes smoothly.

How long does it take to prepare Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole?

Preparation for the irresistible spicy southern cheesy chicken spaghetti casserole typically takes about 20 minutes. This includes cooking the spaghetti and shredding the chicken if necessary. Once prepared, you’ll need to bake the casserole for approximately 30 minutes until it’s bubbly and golden on top. In total, expect to spend around 50 minutes from start to finish, making it a great option for a weeknight dinner or special occasion.

Can I make Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole ahead of time?

Absolutely! You can prepare the irresistible spicy southern cheesy chicken spaghetti casserole ahead of time. After assembling all the ingredients in your baking dish, cover it tightly with plastic wrap or foil and refrigerate it until you’re ready to bake. This make-ahead option is perfect for busy nights or gatherings. Just add an extra 10-15 minutes to the baking time if you’re placing it in the oven straight from the fridge.

What are some variations for Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole?

There are several delicious variations you can try with this irresistible spicy southern cheesy chicken spaghetti casserole. For a healthier twist, substitute whole wheat pasta or add more vegetables like zucchini or spinach. If you prefer a different protein, ground turkey or shrimp work wonderfully too. You can also adjust the heat by adding more spices or using milder cheese options if needed. Get creative and personalize this casserole to fit your taste.

Conclusion for Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole :

In summary, this irresistible spicy southern cheesy chicken spaghetti casserole is a delightful dish that combines creamy textures with zesty flavors. With easy preparation and cooking times, it’s perfect for any occasion. Feel free to customize it with various ingredients that suit your taste preferences. Whether you’re serving it for family dinner or entertaining guests, this casserole is sure to impress everyone at the table. Enjoy creating this comforting meal that embodies southern hospitality!

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